In Vitro and In Vivo evaluation of hydroxypropylmethyl cellulose phthalate capsules
Articles > Article · 2011
Authors: Emel Öykü ÇETİN UYANIKGİL, Makbule Aşıkoğlu, Evren ATLIHAN GÜNDOĞDU, Oya Örümlü, LEVENT KIRILMAZ
International Journal of Drug Delivery; Vol 3, No 2 (2011): International Journal Of Drug Delivery; 279-285, International, Scopus, 2011, vol 3, pp 279-285
Summary
The aim of this study was to develop a novel HPMCP capsule.The HPMCP capsule containing 99m Tc-DTPA and lactose was evaluated in in vitro and in vivo studies.First of all, the HPMCP capsules were prepared and characterized with lenght and diameter size, brittleness facility, moisture content and microbiological test.In vitro resistance and solubility studies of prepared capsules were tested at pH 1.2 and pH 7.4 buffers.The radiolabeled HPMCP capsules were administrated to fasted volunteers.The disintegration times and positions of capsules were recorded by using gamma scintigraphy.In vitro studies showed that HPMCP capsules were gastro resistant for 2 h at pH 1.2 and dissolved at pH 7.4 in 20-25 minutes.The radiolabeled capsules did not disintegrate in stomach whereas disintegrated in intestines.In conclusion, it was found that, the prepared HPMCP capsules can be an alternative to the hard gelatine capsules and used for intestinal targeting.