Global Respiratory Syncytial Virus–Related Infant Community Deaths
Makaleler > Tam Makale · 2021
Yazarlar: Natalie I Mazur, Yvette N Löwensteyn, Joukje E Willemsen, Christopher J Gill, Leah Forman, Lawrence M Mwananyanda, Dianna M Blau, Robert F Breiman, Shabir A Madhi, Sana Mahtab, Emily S Gurley, Shams El Arifeen, Nega Assefa, J Anthony G Scott, Dickens Onyango, Beth A Tippet Barr, Karen L Kotloff, Samba O Sow, Inacio Mandomando, Ikechukwu Ogbuanu, Amara Jambai, Quique Bassat, CHAMPS Network the RSV GOLD Study Group, Somsak Thamthitiwat, Angela Gentile, Maria Florencia Lucion, Márcia Rosane Pires, Fernanda de-Paris, Aubree Gordon, José Félix Sánchez, Marilla G Lucero, Socorro P Lupisan, Bradford D Gessner, Haoua Tall, Natasha Halasa, Najwa Khuri-Bulos, D James Nokes, Patrick K Munywoki, Grieven P Otieno, Katherine L O’Brien, Katherine L Oshitani, Maria Tereza da Costa Oliveira, Carla Cecília de Freitas Lázaro Emediato, Asad Ali, Uzma Bashir Aamir, Daniel E Noyola, Cheryl Cohen, Jocelyn Moyes, Heloisa Ihle Garcia Giamberardino, Jane Melissa Webler, Patricia Gomes de Matos Bezerra, Maria do Carmo Menezes Bezerra Duarte, Helen Y Chu, Rashmi Ranjan Das, Martin W Weber, Nusrat Homaira, Adam Jaffe, Katharine M Sturm-Ramirez, Wei Su, Chiang Chun Yuan, Sandra Chaves, Gideon O Emukule, Sergio de Andrade Nishioka, Felipe Cotrim de Carvalho, Şule GÖKÇE, Sonia M Raboni, Michael Hawkes, Melina Messaoudi, Juliet Bryant, Ghassan S Dbaibo, Rima Hanna-Wakim, J A A Sampath Jayaweera, Kirill Stolyarov, Piyarat Suntarattiwong, Tufária Mussá, Alfredo Bruno, Domenica de Mora, Nasamon Wanlapakorn, Zheng de Xie, Junhong Ai, Jenny Ojeda, Lida Zamora, Evangeline Obodai, John Kofi Odoom, Maha Talaat Ismail, Andrea Buchwald, Cristina O’Callaghan-Gordo, Jaime Fernandez-Sarmiento, Evelyn Obando-Belalcazar, Tapan Dhole, Sheetal Verma, Aykut Eşki, G Ozturk Kartal, Mohammed Al Amad, Abdul Wahed Al Serouri, Yoke FunChan, Jamal I-Ching Sam, Daniel Jarovsky, Daniella Gregória Bomfim Prado da Silva, José Gareca Perales
Clinical Infectious Diseases, Uluslararası, Wos, 2021, cilt 73, ss S229-S237
DOI: 10.1093/cid/ciab528
Özet
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. METHODS: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. RESULTS: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). CONCLUSIONS: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.