Corticosteroids for Skin Delivery: Challenges and New Formulation Opportunities
Kitapta bölümler > Diğer · 2012
Yazarlar: Taner Senyigit, Kevser Özgen ÖZER
Glucocorticoids - New Recognition of Our Familiar Friend, Diğer, Uluslararası, 2012, ,
DOI: 10.5772/53909
Özet
Glucocorticoids -New Recognition of Our Familiar Friend 596 POTENCY DOSE % (w/w) TC Mild Hydrocortisone 1 Hydrocortisone acetate 0.25 Methylprednisolone 0.05 Alclometasone dipropionate 0.01-0.1 Dexamethasone 0.0025 Fluocinolone acetonide 0.75 Fluocortyn butyl ester 0.5 Prednisolone Moderate 0.05 Clobetasone butyrate 0.02 Triamcinolone acetonide 0.005 Fluocinolone acetonide Potent 0.05 Betamethasone dipropionate 0.1 Betamethasone valerate 0.025 Fluocinolone acetonide 0.1 Hydrocortisone butyrate 0.05 Halometasone monohydrate 0.1 Diflucortolone valerate Very potent 0.1 Halcinonide 0.05 Clobetasol propionate Table 1.The currently used TC in various dermatological disorders [3]TC are formulated in a variety of conventional vehicles, including ointments, creams, lotions and gels.In addition to conventional formulations several innovative systems such as nanoparticles, liposomes, microemulsions, foams and patches have been evaluated for different dermatological conditions.Colloidal drug carrier systems, such as liposomes and nanoparticles, could target TC to the viable epidermis, where the inflammatory reactions take place.In particular, liposomal preparations showed a strong affinity for the SC.Patents filed on topical nanoparticulate formulations also claimed the importance of colloidal drug carrier systems for this type of applications [9][10][11][12].This chapter will review major innovations and advances in TC formulations based on the published articles and patent applications.The main factors influencing the effectiveness and bioavailability of TC will be also briefly discussed before emphasizing formulation alternatives. Skin structureThe skin, in Latin called cutis, is considered the largest organ of the body, accounting more than 10% of the body mass and having an average surface of approximately 2 m 2 .