Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia
Makaleler > Tam Makale · 2024
Yazarlar: Selda Aydin, Ali Mert, Mesut Yilmaz, Muna Al Maslamani, Bilal Ahmad Rahimi, Folusakin Ayoade, Amani El-Kholy, Maya Belitova, Buket Erturk Sengel, Sabah Jalal, Ayse Albayrak, Jamayel Adnan Alatawi, Balint Gergely Szabo, Ramesh Shankar Ganeshan, Emmanuel Nsutebu, Aruna Poojary, Yasemin Akkoyunlu, Sevil Alkan, Dilsah Baskol Elik, Gulden Eser-Karlidag, Lurdes Santos, Ruxandra Moroti, Nilguen Altin, Esra Guerbuez, Tuelay uenver Ulusoy, Oğuz Reşat SİPAHİ, Huelya Caskurlu, Aliye Esmaoglu, Botond Lakatos, Nagwa Mostafa El-Sayed, Andrea Marino, Antonio Cascio, Alexandru Mihai, Irina Magdalena Dumitru, Natalia Pshenichnaya, Rezaul Karim Ripon, Mateja Jankovic Makek, Naveed Rashid, Rusmir Baljic, Cosmin Dascalu, Guelden Sincan, Yesim Uygun Kizmaz, Berk Madendere, Hakan Erdem
MYCOSES, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2024, cilt 67, ss e13687-e13687
DOI: 10.1111/myc.13687
Özet
Background: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection.Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021.Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020).Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia.