Labeling of acetaminophen with I-131 and biodistribution in rats
Makaleler > Tam Makale · 2006
Yazarlar: Fatma YURT, Kübra TOPALOĞLU, Yeliz Yildirim, Çiğdem İÇHEDEF
Chemical and Pharmaceutical Bulletin, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2006, cilt 54, ss 245-247
DOI: 10.1248/cpb.54.245
Özet
The aim of the present study was to label acetaminophen (APAP) with I-131 and to determine its radiopharmaceutical potential in rats. Acetaminophen was labeled with I-131 using the iodogen method. The radiochemical purity of 131I-APAP was determined by RTLC and paper electrophoresis. The labeling yield was 94±4%. The biodistribution studies of the labeled compound (specific activity; 56.60 GBq/mmol) were performed in male Albino Wistar rats. The uptake of 131I-APAP in some organs were determined at different time after injection to the rats. The radioactivity in each organ was counted and the percentage of injected activity per gram of tissue weight (%ID/g) for each organ and blood was calculated. 131I-APAP uptake in the lung, liver, kidneys, pancreas, blood, stomach and some brain region, were observed. Thus, 131I-APAP may be radiopharmaceutical for the imaging of the brain. © 2006 Pharmaceutical Society of Japan.