Preparation of L-asparagine complex of technetium-99m
Makaleler > Tam Makale · 1997
Yazarlar: Fatma YURT, Perihan ÜNAK
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 1997, cilt 220, ss 121-124
DOI: 10.1007/bf02035362
Özet
Various methods were experimented to obtain complex of L-asparagine with Tc-99m. The VII state of Tc was reduced with direct reduction by SnCl2 and complex compound could not be obtained. For this reason, ligand exchange with Tc-99m-gluconate complex was tried and 20% yield was obtained. Tc-99m-pyrophosphate complex was carried out as second ligand exchanger and 50% yield was obtained in this experiment. Optimum conditions for ligand exchange with pyrophosphate are pH 11, 50 degrees C temperature, 60 minutes for reaction time and 278 : 1 for pyrophosphate concentration to SnCl2 ratio.