False Negative High Density Lipoprotein- Cholesterol in an Autoimmune Hepatitis Patient: Case Report
Articles > Article · 2010
Authors: Burcu BARUTÇUOĞLU, Guenes Basol, Ahmet Erkin Bozdemır, Secil Kırdok, Sara HABİF, Oya Bayındır
Turkiye Klinikleri Journal of Medical Sciences, Journal Indexed in SCI Expanded, International, WoS, 2010, vol 30, pp 392-398
Summary
False-negative high density lipoprotein-cholesterol (HDL-C) detection is a remarkable condition in clinical laboratory practice. We report an 18-year-old female who admitted to transplantation division, with cirrhotic process of autoimmune hepatitis in which polyclonal hypergammaglobulinemia negatively interfered with HDL-C. The HDL-C and immunoglobulin G (IgG) levels were measured before and after liver transplantation. The patient had high IgG with polyclonal hypergammaglobulinemia and an undetectable HDL-C before transplantation. Falsely undetectable HDL-C levels were ruled out by two easy methods: sample dilution and back calculation based on Friedewald formula. This false negative value of HDL-C was also confirmed with lipoprotein electrophoresis. One must be careful in hyperimmunglobulinemic patients when using direct homogeneous HDL-C assay.