The Influence of Oral Microbiome on Oral Cancer Etiology
Makaleler > Derleme · 2025
Yazarlar: Gaye BÖLÜKBAŞI
International Archives of Dental Sciences, Hakemli Üniversite Dergisi, Ulusal, TR Dizin (Ulakbim), 2025, cilt 46, ss 251-258
Özet
Research on the etiology of cancer suggests that bacteria playing a role in inflammatory processes, in addition to factors such as genetic factors, tobacco and alcohol use, environmental factors, aging, nutrition, and family history, can contribute to the development of cancer in the oral cavity and body.Research evaluating the relationship between inflammation and cancer demonstrates that cancer is not only a cellular-level process but also a complex one involving interactions with the organism's immune system.Studies investigating the relationship between oral cancer and the microbiome emphasize the significant impact of identifying the disease's pathogenic mechanisms on early diagnosis and determining effective treatment strategies.It has been shown that periodontal disease, in particular, may be influential in the development of oral cancer, various bacteria may play a role in cancer development, and changes in the oral microbiome may affect cancer prognosis.Research on the potential roles of bacteria such as C. albicans, Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, and Streptococcus spp. in the development of oral cancer may facilitate the development of new approaches in cancer treatment.In this context, further research into the effects of the oral microbiome on cancer development and prognosis is crucial.