A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome
Makaleler > Tam Makale · 2025
Yazarlar: Kenan Şakar, Barış Akıncı, Ilgın YILDIRIM ŞİMŞİR, Tahir ATİK, Gülhan Akbaba, Neşe Çınar
JCEM Case Reports, SCI İndekslerine Giren Dergi, Uluslararası, Scopus, 2025, cilt 3, ss luaf061-luaf061
Özet
Lipodystrophies are rare disorders characterized by loss of body fat resulting in leptin deficiency. Patients are predisposed to metabolic complications such as severe insulin resistance, hypertriglyceridemia, and hepatic steatosis. Werner syndrome (WS) is among the progeroid syndromes in the classification of lipodystrophy. In this case report, we describe two siblings. In the first case, lipodystrophy was suspected when the patient presented with acute pancreatitis and hypertriglyceridemia, and a diagnosis of WS was confirmed. Subsequently, genetic screening of the patient's sister, who had early-onset diabetes, also revealed WS.