Sustained-release dosage form of phenylpropanolamine hydrochloride. Part I: Microencapsulation and in vitro release kinetics
Makaleler > Tam Makale · 1994
Yazarlar: F. Sevgİ, M. Özyazici, T. Günerİ
Journal of Microencapsulation, Uluslararası, 1994, cilt 11, ss 327-334
DOI: 10.3109/02652049409040462
Özet
Microcapsules of phenylpropanolamine hydrochloride with core:wall ratios of 1:1, 2:1 and 1:2 were prepared by the coacervation-phase separation method, using ethylcellulose as the coating material. Two batches of PPA.HCl powder with different particle sizes (> 58 microns and < 28 microns) were used as the core material. The different sizes of microcapsules were separated using a range of standard sieves (840-247 microns). The effects of drug particle size, the media pH and the core:wall ratio on the dissolution kinetics were studied, and evaluated kinetically.