Effect of hyperbaric oxygen treatment on tendon healing after Achilles tendon repair: an experimental study on rats
Makaleler > Tam Makale · 2012
Yazarlar: Mahmut PEKEDİS
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 46, ss 293-300
Özet
<p>Objective: The aim of this study was to investigate the effects of hyperbaric oxygen treatment on early tendon healing in the treatment of Achilles tendon ruptures.</p><p>Methods: Fifty-six male Wistar albino rats were randomized and divided into two groups. Intratendinous betamethasone was administered preoperatively for degeneration in 28 rats and isoton- ic saline injection was administered to the remaining 28 rats. The Achilles tendons of all rats were sutured following tenotomy. Fourteen rats from each group were then selected and received hyper- baric oxygen therapy. The Achilles tendons were removed, biomechanically evaluated and histopatho- logically studied on the 11th postoperative day. The biomechanical properties and amount of fibrosis, inflammation and vascularization were compared between the groups receiving hyperbaric oxygen therapy and those not.</p><p>Results: Histopathological study showed the amount of fibrosis was significantly higher in the hyper- baric oxygen therapy group than in the control group without the hyperbaric oxygen therapy. The amount of inflammation and vascularization were significantly higher in the steroid administration group than in the no-steroid group. There was a significant difference in the biomechanical proper- ties of the groups in terms of maximum force, stiffness, elastic modulus and maximum allowable stress.</p><p>Conclusion: Hyperbaric oxygen therapy creates a positive histological and biomechanical effect on tendon healing after Achilles tendon repair.</p><p>Key words: Achilles tendon; biomechanics; hyperbaric oxygen.</p>