Differential expression of receptor activator of nuclear factor-kappa B ligand and osteoprotegerin mRNA in periodontal diseases
Articles > Article · 2007
Authors: N. BOSTANCI, T. ILGENLI, Gülnur EMİNGİL, B. AFACAN, B. HAN, Hüseyin TÖZ, Afig BERDELİ, FATMA GÜL ATİLLA, I. J. MCKAY, F. J. HUGHES, G. N. BELIBASAKIS
JOURNAL OF PERIODONTAL RESEARCH, Journal Indexed in SCI Expanded, International, 2007, vol 42, pp 287-293
DOI: 10.1111/j.1600-0765.2006.0094.x
Summary
Background and Objective: Receptor activator of nuclear factor-kappa B ligand (RANKL) is responsible for the induction of osteoclastogenesis and bone resorption, whereas its decoy receptor, osteoprotegerin, can directly block this action. Because this dyad of cytokines is crucial for regulating the bone remodelling process, imbalances in their expression may cause a switch from the physiological state to enhanced bone resorption or formation. This study investigated the mRNA expression of RANKL and osteoprotegerin, as well as their relative ratio, in the gingival tissues of patients with various forms of periodontal diseases.