Genetic imaging study with [Tc-(99m)] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate
Makaleler > Tam Makale · 2018
Yazarlar: Aynur Pekcanlar Akay, Gamze Capa Kaya, Samet Kose, Cigdem Eresen Yazicioglu, Handan Ozek Erkuran, Sevay Alsen Guney, Kaya Oguz, Duygu Keskin, Burak Baykara, Neslihan Inal Emiroglu, Mine Sencan Eren, Sefa Kizildag, Turkan Ertay, Dua Ozsoylu, Suha Miral, Hatice Durak, Ali Saffet GÖNÜL, Luis Augusto ROHDE
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2018, cilt 86, ss 294-300
DOI: 10.1016/j.pnpbp.2018.04.00
Özet
Aim: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-(99m)] TRODAT-1SPECT in a sample of treatment-naive adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability.