Lung cancer in patients with pulmonary fibrosis: characteristics features and prognosis.
Makaleler > Tam Makale · 2024
Yazarlar: SİBEL KARA, Nesrin MOĞULKOÇ BISHOP, GAMZE KIRKIL, ERDOĞAN ÇETİNKAYA, ÖMER ÖZBUDAK, TALAT KILIÇ, FATMA DEMİRCİ ÜÇSULAR, BARIŞ DEMİRKOL, DİLDAR DUMAN, GÜLİSTAN KARADENİZ, NURHAN KÖKSAL, YASEMİN SÖYLER, HÜLYA GÜNBATAR, ÖZLEM ORUÇ, UTKU TAPAN, KÜBRA ELİF AKBAŞ, Ömer Selim UNAT
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, SCI İndekslerine Giren Dergi, Uluslararası, 2024, cilt 41, ss e2024050-e2024050
DOI: 10.36141/svdld.v41i4.15675
Özet
BACKGROUND AND AIM: Lung cancer is one of the significant comorbidities seen in patients with Idiopathic Pulmonary Fibrosis (IPF). However, there is limited data on non-IPF Pulmonary Fibrosis (PF) patients with lung cancer (LC). The present study aims to compare the characteristics and survival outcomes of patients diagnosed with LC in IPF and non-IPF PF. METHODS: The multicenter data records of IPF and non-IPF PF patients diagnosed with lung cancer between 2010- 2022 were analyzed in this descriptive, cross-sectional, and retrospective study. RESULTS: Of the 251 patients involved in this study [164 IPF-LC, 87 non-IPF PF-LC], 89.6% were male, the mean age was 69±7.9 years and the smoking rate was 85.7%. Honeycomb pattern was more frequently observed in IPF-LC patients [62.8%,37.9%p<0.001], whereas ground-glass opacity [33.5%,59.8%p<0.001] and emphysema [37.8%,59.8%p<0.001] were more frequently seen in non-IPF PF-LC patients. The most commonly seen histological type was squamous cell carcinoma [42.7%,33.9%], followed by adenocarcinoma [28.2%; 32.2%]. [46.4%;47.2%] and their 5-year mortality rates were high [64.6%, 63.2%]. The median survival for both groups was 2±0.22 years [median 95% CI (1.55-2.44)]. The shortest survival time was observed in non-IPF PF-LC subgroup with unclassified PF [1±0.253 years median 95% CI (0.50-1.49) (p=0.030)]. CONCLUSIONS: The majority of IPF and non-IPF PF LC patients were male, elderly, and had a high smoking rate. Squamous cell carcinoma was the most frequently seen histological type and they had short survival periods and high mortality rates. The survival period of unclassified non-IPF PF-LC patients was found to be the shortest.