Gingival tissue proteoglycan and chondroitin-4-sulphate levels in cyclosporin A-induced gingival overgrowth and the effects of initial periodontal treatment
Articles > Article · 2005
Authors: S VARDAR, H BAYLAS, Figen ZİHNİOĞLU, Nurcan Gülsüm BUDUNELİ, Gülnur EMİNGİL, FATMA GÜL ATİLLA
JOURNAL OF CLINICAL PERIODONTOLOGY, Journal Indexed in SCI Expanded, International, 2005, vol 32, pp 634-639
DOI: 10.1111/j.1600-051x.2005.00724.x
Summary
Objectives: Cyclosporin A (CsA) is a potent immunosuppressive drug used in organ transplant patients to prevent graft rejection. CsA-induced gingival overgrowth is one of the side effects of this drug and its pathogenesis is still unclear. The present study was planned to comparatively analyse total proteoglycan (PG) and chondroitin-4-sulphate (C4S) levels in CsA-induced overgrown gingival tissue samples obtained before and after initial periodontal treatment and to compare these findings with the situation in healthy gingiva.