The total synthesis of the pavine alkaloid thalimonine
Articles > Article · 1997
Authors: Mehmet Varol PABUÇÇUOĞLU, M HESSE
HETEROCYCLES, Journal Indexed in SCI Expanded, International, 1997, vol 45, pp 1751-1758
Summary
The synthesis of the pavine alkaloid (+/-)-thalimonine (1) by the acid-mediated cyclization of the corresponding 1,2-dihydroisoquinoline (10) is reported. The latter compound was synthesized by a multistep reaction from 4-methoxy-2,3-methylenedioxybenzaldehyde. The resolution of (+)-1 to its (-)-enantiomer was performed.