Characterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017
Makaleler > Tam Makale · 2020
Yazarlar: MEHMET CEYHAN, YASEMİN ÖZSÜREKCİ, Jay Lucidarme, Ray Borrow, Nezahat Gurler, MELİKE EMİROĞLU, Fatma Nur Oz, Nuri Zafer KURUGÖL, Umit Celik, Ashnur Ozkaya Parlakay, ENER ÇAĞRI DİNLEYİCİ, Adem Karbuz, SOLMAZ ÇELEBİ, Ilker Devrim, Gamze Gulfidan, ÖZLEM ÖZGÜR GÜNDEŞLİOĞLU, Mihriban Yucel, Emel Ulusoy, ALİ BÜLENT CENGİZ, NURŞEN BELET
VACCINE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2020, cilt 38, ss 3545-3552
DOI: 10.1016/j.vaccine.2020.03.024
Özet
Diverse Neisseria meningitidis strains belonging to various serogroups and clonal complexes cause epidemic and endemic life-threatening disease worldwide. This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37.5% of all pediatric (ages 0-18 years) invasive meningococcal disease cases in Turkey from January 2013 to December 2017, underwent genome sequence analysis. Thirty-six (66.7%) isolates were MenB, 10 (18.5%) were serogroup W (MenW), 4 (7.4%) were serogroup A (MenA), 3 (5.6%) were serogroup Y (MenY) and 1 (1.8%) was serogroup X (MenX). The MenB isolates were diverse with cc35 (19.4%), cc41/44 (19.4%) and cc32 (13.8%) as the most prevalent clonal complexes. The MenW isolates (n = 10) comprised cc11 (n = 5), ST-2754 (cc-unassigned; n = 4) and cc22 (n = 1). gMATS was indicative of high 4CMenB coverage (72.2-79.1%) of Turkish invasive MenB strains from pediatric patients. Strain coverage of several clonal complexes differed from that seen elsewhere in Europe highlighting the importance of performing local assessments and also the use of phenotypic methods, i.e. MATS, where possible. All of the isolates possessed in-frame fhbp alleles and so were potentially covered by MenB-fHbp. Continued surveillance is essential to guide recommendations for current and future vaccines as well as understanding changes in epidemiology. (C) 2020 Elsevier Ltd. All rights reserved.