Altered level of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/REF-1) mRNA in the hippocampus of ovariectomized rats treated by raloxifene against kainic acid
Makaleler > Tam Makale · 2005
Yazarlar: Ayfer YALÇIN, Lütfiye KANIT, Güliz ARMAGAN, SEHNAZ SARGIN, Mustafa Coşan TEREK, Muhammed Bahattin TANYOLAÇ
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2005, cilt 32, ss 611-614
DOI: 10.1111/j.0305-1870.2005.04239.x
Özet
1. Accumulated clinical evidence suggests that selective oestrogen receptor modulators (SERM), such as raloxifene, may be neuroprotective. Oxidative stress is a likely molecular mechanism in the neurotoxicity of kainic acid (KA), an excitotoxic substance. The expression levels of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) gene seem to correlate with cellular sensitivity to reactive oxygen species (ROS) and a reduction in the expression of APE/Ref-1 may cause oxidative DNA damage.