Splenic Marginal Zone Lymphoma in Turkey: Association With Hepatitis B Instead Of Hepatitis C Virus As An Etiologic and Possible Prognostic Factor-Multicenter Cohort Study
Makaleler > Tam Makale · 2019
Yazarlar: Mufide Okay, Tuncay Aslan, Evren Ozdemir, AYŞEGÜL ÜNER, Arzu Saglam, Elif Gungor, Ayse Uysal, Nevin Alayvaz Aslan, Esra Yildizhan, Abdullah Agit, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroglu, Serdar Sivgin, Gulsum Akgun Cagliyan, Sinan Demircioğlu, İBRAHİM BARIŞTA, Esra Ozhamam, Filiz VURAL, Bulent Eser, Gulsum Ozet, Rahşan YILDIRIM, Mehmet Hilmi Dogu, Ilhami Berber, MEHMET ALİ ERKURT, Umit Yavuz Malkan, Fevzi Altuntas, YAHYA BÜYÜKAŞIK
Turkish Journal of Hematology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2019, cilt 37, ss 84-90
DOI: 10.4274/tjh.galenos.2019.2019.0177
Özet
Objective: Chronic antigenic stimulation is frequently blamed in the pathogenesis of extranodal marginal zone lymphomas including splenic marginal zone lymphoma (SMZL). Chronic hepatitis C is frequently observed in SMZL patients in some geographical regions. However, these reports are largely from North America and Europe, and data from other countries are insufficient. In this multicenter study we aimed to identify the clinical characteristics of SMZL patients in Turkey, including viral hepatitis status and treatment details. Materials and Methods: Data were gathered from participating centers from different regions of Turkey using IBM SPSS Statistics 23 for Windows. Hepatitis B virus surface antigen (HBsAg), anti-HBs antibody, anti-HB core antigen antibody (anti-HBcAg), HB viral load, anti-hepatitis C virus (HCV) antibody, HCV viral load results were analyzed. Results: -microglobulin, and HBsAg positivity were associated with increased risk of death. Only albumin remained significant in multivariable analysis. Conclusion: These results indicate that hepatitis B virus may be a possible risk factor for SMZL in our population. It may also be an indirect prognostic factor.