Exosomal IncRNA-p21 levels may help to distinguish prostate cancer from benign disease
Articles > Article · 2015
Authors: Mustafa Isin, Ege Uysaler, Emre ÖZGÜR, Hikmet Koseoglu, Oner Sanli, Ömer Barış YÜCEL, Uğur GEZER, Nejat Dalay
FRONTIERS IN GENETICS, Journal Indexed in SCI Expanded, International, 2015, vol 6
Summary
Exosomes are membranous vesicles containing various biomolecules including IncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 IncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of IncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.