Leflunomide: is a new oral agent in treatment of acute pancreatitis?
Articles > Article · 2010
Authors: Ufuk Kutluana, Nevin ORUÇ, Deniz NART, Bunyamin Kaptanoglu, Nadir Yonetci, Ahmet Ömer ÖZÜTEMİZ
Pancreas, Journal Indexed in SCI Expanded, International, 2010, vol 39, pp 237-242
DOI: 10.1097/mpa.0b013e3181bab6a9
Summary
Objectives: Nuclear factor-kappa B (NF-kappa B) is a potent mediator in several steps of acute pancreatitis. Leflunomide is a novel immunomodulating drug that is also a potent inhibitor of NF-kappa B activation. The aim of this study was to investigate the effects of leflunomide pretreatment in severe necrotizing pancreatitis in rats.