Leflunomide: is a new oral agent in treatment of acute pancreatitis?
Makaleler > Tam Makale · 2010
Yazarlar: Ufuk Kutluana, Nevin ORUÇ, Deniz NART, Bunyamin Kaptanoglu, Nadir Yonetci, Ahmet Ömer ÖZÜTEMİZ
Pancreas, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2010, cilt 39, ss 237-242
DOI: 10.1097/mpa.0b013e3181bab6a9
Özet
Objectives: Nuclear factor-kappa B (NF-kappa B) is a potent mediator in several steps of acute pancreatitis. Leflunomide is a novel immunomodulating drug that is also a potent inhibitor of NF-kappa B activation. The aim of this study was to investigate the effects of leflunomide pretreatment in severe necrotizing pancreatitis in rats.