Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Makaleler > Tam Makale · 2023
Yazarlar: Anna L. Peljto, Rachel Z. Blumhagen, Avram Walts, Jonathan Cardwell, Julia Powers, Tamera J. Corte, Joanne L. Dickinson, Ian Glaspole, Yuben Moodley, Martina Vašáková, Elisabeth Bendstrup, Jesper Rømhild Davidsen, Raphaël Borie, Bruno Crestani, Philippe Dieudé, Francesco Bonella, Ulrich Costabel, Gunnar Guðmundsson, Seamas C Donnelly, Jim Egan, Michael T. Henry, Michael P. Keane, Marcus P. Kennedy, Cormac McCarthy, Aoife McElroy, Joshua A. Olaniyi, Katherine Ma O'Reilly, Luca Richeldi, Paolo Maria Leone, Venerino Poletti, Francesco Puppo, Sara Tomassetti, Valentina Luzzi, Nurdan Köktürk, Nesrin Moğulkoç, Christine Fiddler, Nikhil Hirani, R. Gisli Jenkins, Toby M. Maher, Philip L. Molyneaux, Helen Parfrey, Rebecca Braybrooke, Timothy S. Blackwell, Peter Jackson, Steven D. Nathan, Mary K. Porteous, Kevin K. Brown, Jason D. Christie, Harold R. Collard, Oliver Eickelberg, Elena Foster, Kevin F. Gibson, Marilyn K. Glassberg, Daniel J. Kass, Jonathan A. Kropski, David J. Lederer, A. Linderholm, JE Loyd, Susan K. Mathai, Sydney B. Montesi, Imre Noth, Justin M. Oldham, Amy Palmisciano, Cristina Reichner, Mauricio Rojas, Jesse Roman, Neil W. Schluger, Barry S. Shea, Jeffrey J. Swigris, Paul J. Wolters, Yingze Zhang, Cecilia M. Prêle, Juan Ignacio Enghelmayer, María Otaola, Christopher J. Ryerson, Mauricio Salinas, Martina Šterclová, Tewodros Haile Gebremariam, Marjukka Myllärniemi, Roberto Carbone, Haruhiko Furusawa, Masaki Hirose, Yoshikazu Inoue, Yasunari Miyazaki, Ken Ohta, Shin Ohta, Tsukasa Okamoto, Dong Soon Kim, Annie Pardo, Moisés Selman, Alvaro U. Aranda, Moo Suk Park, Jong Sun Park, Jin Woo Song, María Molina-Molina, Lurdes Planas‐Cerezales, Gunilla Westergren‐Thorsson, Albert V. Smith, Ani Manichaikul, John S. Kim
Greater South Information System, Uluslararası, 2023
DOI: 10.60692/8f8sg-zra34
Özet
Count: 3,247 Rare variants within the TERT and RTEL1 genes and well-established common variants have the largest contribution to IPF risk overall.Efforts in risk profiling or development of therapies for IPF that focus on TERT, RTEL1, common variants, and environmental risk factors are likely to have the largest impact on this complex disease.