Expression profiling of RE1-silencing transcription factor (REST), REST corepressor 1 (RCOR1), and Synapsin 1 (SYN1) genes in human gliomas
Makaleler > Tam Makale · 2016
Yazarlar: Musteyde YUCEBAS, Sunde Yilmaz SUSLUER, Hasan Onur CAGLAR, Tugce BALCI, Z. Ozlem Dogan SIGVA, Taner AKALIN, Nezih OKTAR, Tayfun DALBASTI, Çığır BİRAY AVCI, Cumhur GÜNDÜZ
JOURNAL OF BUON, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2016, cilt 21, ss 964-972
Özet
Purpose: The repressor element 1 (RE-1) silencing transcription factor (REST) is a transcription factor which represses the expression of neuronal differentiation-related genes including SYN1 gene. CoREST, encoded by RCOR1 gene, binds to the REST protein for remodeling of chromatin structure. Although there is a relation among REST, RCOR1, and SYN1 genes, the role of these genes in glioma tumors is still unclear. In this study, expressions of REST, RCOR1, and SYN1 genes were detected in primary cultures derived from tumor samples of diffuse astrocytoma (DA), anaplastic oligodendroglioma (AO), and glioblastoma multiforme (GBM) cases.