Antifungal and Antibiofilm Activities of Selective Serotonin Reuptake Inhibitors Alone and in Combination with Fluconazole.
Makaleler > Tam Makale · 2020
Yazarlar: Yamaç Tekintaş, Aybala Temel, Ayşegül ATEŞ DEĞİRMENCİ, Bayrı ERAÇ, Dilek Yeşim METİN, Süleyha HİLMİOĞLU POLAT, Mine HOŞGÖR LİMONCU
Turkish journal of pharmaceutical sciences, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2020, cilt 17, ss 667-672
DOI: 10.4274/tjps.galenos.2019.65481
Özet
Objectives: Candida spp. are clinically important pathogens that cause difficulties for treatment by biofilm formation. Considering antifungal resistance rates and the limitations in the discovery of new antifungals, the antifungal and antibiofilm effects of various drugs used for different therapeutic purposes are becoming more important. The goal of our study was to determine the antifungal and antibiofilm effects of the selective serotonin reuptake inhibitors (SSRIs), namely sertraline (SRT), paroxetine (PRX), and fluoxetine (FLX) alone and in combination with fluconazole (FLC) against Candida spp.