Clinical characteristics and risk factors of patients with cystic fibrosis-related diabetes and pre-diabetes: cohort of cystic fibrosis registry of Türkiye
Makaleler > Tam Makale · 2026
Yazarlar: Mehmet Mustafa ÖZASLAN, Gökçen KARTAL ÖZTÜRK, Figen GÜLEN, Ezgi Demirdöğen, Nazan Çobanoğlu, Merve Nur Tekin, Ayşen Bingöl, Abdurrahman Erdem Başaran, Velat Şen, Edip Ünal, Sibel Doğru, Beste Özsezen, Mehmet Köse, Ali Ersoy, Mehmet Kılıç, Hasan Yüksel, Azer Kılıç Başkan, Ayşe Ayzıt Kılınç Sakallı, Erkan Çakır, Mina Hızal, Hülya Anıl, Tuğba Şişmanlar Eyüboğlu, Handan Kekeç, Ayşe Tana Aslan, Meltem Yıldız Kayaoğlu, Emine Altay Tanyer, Nagehan Emiralioğlu, Ebru Yalçın, Sevgi Pekcan, Suat Savaş, Bahar Ece Tokdemir, Derya Ufuk Altıntaş, Mahir Serbes, Ali Özdemir, Oğuz Karcıoğlu, Burak Kağan Elçi, Yakup Canıtez, Uğur Özçelik, Deniz Doğru Ersöz
Journal of Pediatric Endocrinology and Metabolism, Uluslararası, Wos, 2026, cilt 39, ss 440-448
Özet
Abstract Objectives Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). This study aimed to determine the prevalence and risk factors of CFRD using data from the CF Registry of Türkiye (CFRT). Methods All patients with CF who underwent diabetes screening in 2022 or earlier were included in the study. The clinical and demographic characteristics of patients with CFRD, pre-diabetes (impaired glucose tolerance, impaired fasting glucose, indeterminate glucose tolerance), and those with normal screening results (NSR) were compared. Results Of the 1,702 patients registered in the data system in 2022, 916 patients from 21 centers who underwent diabetes screening were included in the study. CFRD was diagnosed in 102 patients (11.2 %), there were 56 patients (6.1 %) with pre-diabetes, and NSR were found in 757 patients (82.7 %). The youngest patient diagnosed with diabetes was 6 years old. In patients with CFRD, the median age of patients was found to be higher (p<0.001), body mass index (BMI) was found to be lower (p 0.017); chronic Pseudomonas aeruginosa (P. aeruginosa) colonization (p<0.001), severe mutations (60.8 %, p<0.001), and pancreatic insufficiency (56.1 %, p<0.001) were more frequent; median FEV1% and FVC% values were significantly lower (p<0.001 and p<0.002, respectively) compared to non-diabetic patients. Conclusions CFRD is associated with impaired pulmonary function, poor nutritional status, and increased chronic bacterial colonization of the airways. Advanced age, decreased respiratory function, severe genotype, and pancreatic insufficiency are risk factors for CFRD.