Large joint and lower extremity involvement have higher impact on disease outcomes in oligoarticular psoriatic arthritis
Makaleler > Tam Makale · 2020
Yazarlar: Gizem Ayan, DİLEK SOLMAZ, Sibel Bakirci, Ilaria Tinazzi, Ahmet Omma, Orhan Kucuksahin, Cem Ozisler, Sule Yavuz, Ozun Bayindir, Gezmis Kimyon, Atalay DOĞRU, EMİNE FİGEN TARHAN, Meryem Can, LEVENT KILIÇ, MEHMET TUNCAY DURUÖZ, Kenan AKSU, UMUT KALYONCU, Sibel Zehra Aydin
International Journal of Rheumatic Diseases, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 23, ss 1094-1099
Özet
OBJECTIVE: Joints with different sizes and anatomical locations can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of different joint patterns on patient-reported outcomes (PROs) in patients with mono-oligoarthritis. METHODS: Within PsArt-ID (Psoriatic Arthritis- International Database), 387/1670 patients who had mono-oligoarthritis (1-4 tender and swollen joints) were enrolled in cross-sectional assessment. The joints were categorized according to their size (small/large) and location (upper/lower extremity) and PROs, physician global assessment and C-reactive protein (CRP) were compared. Analysis was made by categorizing according to joint counts (1-2 joints/ 3-4 joints). RESULTS: The mean age (SD) was 46.9 (14.24) with a mean (SD) PsA duration of 3.93 (6.03) years. Within patients with 1-2 involved joints (n = 302), size of the joints only had an impact on CRP values with large joints having higher CRP (P = .005), similar to lower extremity involvement (P = .004). PROs were similar regardless of size or location if 1-2 joints were inflamed. Within patients with 3-4 involved joints (n = 85), patient global assessment (PGA), pain, fatigue and physician global assessment were higher in the group with large joints. Similarly, PGA, pain, and physician global assessment were higher in patients with lower extremity involvement as well as higher CRP values. CONCLUSION: For PsA patients with 3-4 joints involved, lower extremity and large joints are associated with poorer outcomes with worse PROs, physician global assessment, and higher CRP. The size and anatomical location of the joints are less important for patients with 1-2 joints in terms of the PROs.