11-Hydroxy-2,4-cycloeudesmane from the Leaf Oil of Juglans regia and Evaluation of its Larvicidal Activity
Makaleler > Tam Makale · 2016
Yazarlar: Ayşegül Köroğlu, Ayşe Baldemir, Gülmira Özek, Erdal Bedir, Nurhayat Tabanca, Abbas Ali, Ikhlas A. Khan, Kemal Hüsnü Can Başer, Temel Özek
Natural Product Communications, Uluslararası, Wos, 2016, cilt 11, ss 1421-1424
DOI: 10.1177/1934578x1601101002
Özet
Leaves of Juglans regia L. collected from two different locations [Adana (A) and Ankara (B)] from Turkey were subjected to hydrodistillation in a Clevenger type apparatus to yield the essential oils (EOs). GC/MS and GC-FID analyses revealed that the A EO was rich in thymol (23.1%), while caryophyllene oxide (33.8%) was found as the main constituent of B EO. Both contained P-eudesmol (1.4% - 9.5 %), (E)-geranyl acetone (3.7% - 5.8%) and the eudesmane type constituent juglaterpene A (3.1% - 11.0%). Using a HP Innowax preparative capillary column connected to a preparative fraction collector, an unknown constituent, juglaterpene A (1, 1 l-hydroxy-2,4-cycloeudesmane), was isolated in a rapid one-step manner with > 94.0% purity. Structure determination was accomplished from ID- and 2D-NMR spectroscopic data. Oil B demonstrated significant larvicidal activity against 1st instar Aedes aegypti L.