Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562
Articles > Article · 2015
Authors: Ceyda TUNAKAN DALGIÇ, Burçin KAYMAZ, Melda Comert Ozkan, Aysegul Dalmizrak, Fahri ŞAHİN, Güray SAYDAM
Clinical Lymphoma Myeloma and Leukemia, Journal Indexed in SCI Expanded, International, WoS, 2015, vol 15, pp S161-S166
DOI: 10.1016/j.clml.2015.02.012
Summary
We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway associated malignancies after confirmation with clinical studies. (C) 2015 Elsevier Inc. All rights reserved.