In vivo biological evaluation of I-131 radiolabeled-paclitaxel glucuronide (I-131-PAC-G)
Articles > Article · 2012
Authors: O. Aslan, Fazilet Zümrüt BİBER MÜFTÜLER, Ayfer YURT KILÇAR, Çiğdem İÇHEDEF, Perihan ÜNAK
RADIOCHIMICA ACTA, Journal Indexed in SCI Expanded, International, 2012, vol 100, pp 339-345
Summary
Paclitaxel (PAC) is a natural occurring diterpene alkoloid originally isolated from the bark of Taxus Brevifolia. It is one of the most important antitumor agents for clinical treatment of ovarian, breast non-small cell lung and prostate cancers. It is known that these types of cancer cells have high beta-glucuronides enzyme which can catalyze the hydrolysis of glucuronides. This is why the synthesis compounds which undergo glucuronidation come into question in the imaging and therapy of these cancer cells.