In vivo biological evaluation of I-131 radiolabeled-paclitaxel glucuronide (I-131-PAC-G)
Makaleler > Tam Makale · 2012
Yazarlar: O. Aslan, Fazilet Zümrüt BİBER MÜFTÜLER, Ayfer YURT KILÇAR, Çiğdem İÇHEDEF, Perihan ÜNAK
RADIOCHIMICA ACTA, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 100, ss 339-345
Özet
Paclitaxel (PAC) is a natural occurring diterpene alkoloid originally isolated from the bark of Taxus Brevifolia. It is one of the most important antitumor agents for clinical treatment of ovarian, breast non-small cell lung and prostate cancers. It is known that these types of cancer cells have high beta-glucuronides enzyme which can catalyze the hydrolysis of glucuronides. This is why the synthesis compounds which undergo glucuronidation come into question in the imaging and therapy of these cancer cells.