Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145
Makaleler > Tam Makale · 2008
Yazarlar: Yuksel KUCUKZEYBEK, Mustafa K. GUL, Ercument CENGIZ, Cigdem ERTEN, Burcak KARACA, Gurbuz GORUMLU, Harika Atmaca, Selim Uzunoglu, BÜLENT KARABULUT, Ulus Ali ŞANLI, RÜÇHAN USLU
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2008, cilt 27
Özet
Background: The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid (ATRA) could potently inhibit the growth of prostate cancer cells in vitro and its combination with various anticancer agents results in increased cytotoxicity. Based on these data, our aim was to examine the synergistic/additive cytotoxic and apoptotic effects of combination of docetaxel and ATRA, in hormone- and drug refractory human DU-145 prostate cancer cells. Furthermore, we have searched for the underlying mechanisms of apoptosis by demonstrating apoptosis-related genes.