Optimal adjuvant treatment strategies for TNBC patients with residual disease after neoadjuvant treatment
Makaleler > Tam Makale · 2023
Yazarlar: Deniz Can Guven, HASAN ÇAĞRI YILDIRIM, Fatih Kus, Enes Erul, Neyran Kertmen, Omer Dizdar, Sercan Aksoy
EXPERT REVIEW OF ANTICANCER THERAPY, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2023, cilt 23, ss 1049-1059
DOI: 10.1080/14737140.2023.2218090
Özet
IntroductionThe therapeutic armamentarium for the neoadjuvant treatment of triple-negative breast cancer (TNBC) has significantly expanded with the hopes of improving pathological complete response (pCR) rates and the possibility of a cure. However, the data on optimal adjuvant treatment strategies for patients with residual disease after neoadjuvant treatment is limited.Areas coveredWe discuss the available data on adjuvant treatment for residual TNBC after neoadjuvant treatment considering clinical trials. Additionally, we discuss ongoing trials to give perspectives on how the field may evolve in the next decade.Expert opinionThe available data support the use of adjuvant capecitabine for all patients and either adjuvant capecitabine or olaparib for patients with germline BRCA1 and BRCA2 mutations, according to availability. The CREATE-X study of capecitabine and OlympiA study of olaparib demonstrated disease-free and overall survival benefits. There is an unmet need for studies comparing these two options for patients with germline BRCA mutations. Further research is needed to delineate the use of immunotherapy in the adjuvant setting, molecular targeted therapy for patients with molecular alterations other than germline BRCA mutation, combinations, and antibody-drug conjugates to further improve outcomes.