Effect of Folic Acid in Sepsis-induced Lung Damage in Rats
Makaleler > Tam Makale · 2023
Yazarlar: GÜNER YURTSEVER, EJDER SAYLAV BORA, EBRU EROĞLU, Yiğit UYANIKGİL, MÜMİN ALPER ERDOĞAN, OYTUN ERBAŞ
Medical Records, Hakemli Üniversite Dergisi, Uluslararası, TR Dizin (Ulakbim), 2023, cilt 5, ss 87-92
Özet
Aim: Sepsis-induced lung injury remains a critical concern with significant morbidity and mortality. This study aimed to investigate the potential therapeutic role of Folic Acid in mitigating lung injury induced by sepsis while exploring its interaction with the soluble suppression of tumorigenicity 2 (sST2) protein in an experimental rat model. Material and Methods: Rats were divided into three groups: a normal control group, a group induced with sepsis and treated with saline, and a group induced with sepsis and treated with Folic Acid (5 mg/kg). Biomarkers of oxidative stress, inflammation, respiratory gas exchange, and lung histopathology were assessed. Results: Folic Acid administration resulted in significantly decreased Malondialdehyde (MDA) levels (p