Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages
Articles > Article ยท 2013
Authors: Eugene O. APOSTOLOV, Ercan OK, Samuel BURNS, Safia NAWAZ, Alena SAVENKA, Sudhir V. SHAH, Alexei G. BASNAKIAN
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Journal Indexed in SCI Expanded, International, 2013, vol 20, pp 878-892
Summary
Aim: Both oxidized LDL and carbamylated LDL are considered important for initiating atherosclerosis in patients with end-stage kidney disease through vascular endothelial cell dysfunction or injury. However their effects on each other and their relationship related to pro-atherosclerotic effects on endothelial cells and macrophages have not been investigated. In this study, we analyzed the competition between LDL carbamylation and oxidation, tested biological effects of carbamylated-oxidized LDL (coxLDL) toward the endothelial cells, assessed its ability to cause foam cell development, and determined the roles of scavenger receptors in this process.