Mild obstructive sleep apnoea (OSA) and arterial hypertension in the EuropeanSleep Apnoea Database (ESADA) cohort study.
Bildiriler > Özet Bildiri · 2018
Yazarlar: Izolde Bouloukaki, Paschalis Steiropoulos, Marisa BONSIGNORE, Walter Mcnicholas, Jan HEDNER, Ludger GROTE, Oreste MARRONE, Johan VERBRAECKEN, Özen KAÇMAZ BAŞOĞLU, Gianfranco PARATİ, Carolina Lombardi, Athanasia Pataka, Sophia Schiza
Sleep and control of breathing, Fransa, Uluslararası, Sözlü Sunum, Özet Bildiri, 2018-2018, Wos, cilt 52, ss OA4964-OA4964
DOI: 10.1183/13993003.congress-2018.oa4964
Özet
Background: Mild obstructive sleep apnoea (OSA) is highly prevalent, however its association with important clinical outcomes like arterial hypertension remains unknown. Aims and Objectives: To investigate the association between mild OSA and arterial hypertension in the European Sleep Apnoea Database (ESADA) cohort after adjusting for relevant confounding factors. Methods: A multicentric sample of 4974 adults from the ESADA cohort who showed simple snoring or mild OSA at cardiorespiratory polygraphy was studied. We compared the predictive value of mild OSA (AHI 5-<15n/h) compared to non-apnoeic snorers on prevalent physician-diagnosed hypertension after adjustment for relevant confounding factors including gender, age, smoking, obesity, daytime sleepiness, dyslipidemia, chronic obstructive pulmonary disease and type 2 diabetes. Results: Arterial hypertension prevalence was 37% in mild OSA patients (n=2457) compared to 20% in non-apnoeic snorers (n=2517, p<0.001). Mild OSA independently predicted prevalent hypertension after adjustment for confounders [odds ratio (95% CI) 1.43 (1.22–1.68), p<0.001]. Other independent factors associated with prevalent hypertension were waist-hip ratio [odds ratios (95% CI) 6.38 (1.85–21.98), p=0.003], type 2 diabetes [odds ratios (95% CI) 2.99 (2.29–3.91), p<0.001], and hyperlipidemia [odds ratios (95% CI) 3.08 (2.49–3.80), p<0.001]. Conclusions: Mild OSA was associated with an independent 43% risk increase for arterial hypertension in this large, multicentric clinical patient cohort.