25-Hydroxyvitamin-D levels in Sjögren's syndrome: Is it the right time to dismiss the case or not?
Makaleler > Tam Makale · 2024
Yazarlar: Gonca Karabulut, Zevcet Yilmaz, Ilgın YILDIRIM ŞİMŞİR, Burcu BARUTÇUOĞLU, GÖKSEL TANIGÖR
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, ss 1-6
Özet
This study aimed to investigate whether patients with Primary Sjögren Syndrome (SjS) have different levels of 25 OH-D3 (Vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 » nmol/L or ≥50 » nmol/L). The disease activity was evaluated using The EULAR Sjögren's syndrome (SS) disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correlations were found between patient characteristics or laboratory values (p>0.05). This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.