Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism
Articles > Article · 2017
Authors: Serkan Yener, Leyla Demir, Mustafa DEMİRPENCE, Mustafa Mahmut Baris, Ilgın YILDIRIM ŞİMŞİR, Secil Ozisik, Abdurrahman Comlekci, Tevfik Demir
Endocrine, Journal Indexed in SCI Expanded, International, WoS, 2017, vol 56, pp 308-316
DOI: 10.1007/s12020-017-1268-7
Summary
Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.