Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
Makaleler > Tam Makale · 2020
Yazarlar: Refik Bademci, Mümin Alper Erdoğan, Ali Yücel Kara, Gürkan Yiğittürk, Oytun Erbaş
Acta Cirúrgica Brasileira, Uluslararası, Wos, 2020, cilt 35, ss e202000404-e202000404
DOI: 10.1590/s0102-865020200040000004
Özet
PURPOSE: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. METHODS: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. RESULTS: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). CONCLUSION: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.