Synthesis of a 99mTc labeled estrogen-derivative and the determination of its radiopharmaceutical potential on rats
Makaleler > Tam Makale · 2004
Yazarlar: HÜSEYİN ENGİNAR, Perihan ÜNAK, Fatma YURT, Fazilet Zümrüt BİBER MÜFTÜLER
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2004, cilt 260, ss 339-349
DOI: 10.1023/b:jrnc.0000027107.43043.37
Özet
An estrogen derivative 1-(3, 17-alpha-estradiolyl propin-1-yl-3-(1,4,8,11-tetraazacyclotetradecyl)-propanate (ESTACPA) was synthesized. The product was purified by HPLC and characterized by NMR and IR spectroscopy. The synthesized compound was labeled with Tc-99m. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacrificed and their organs were removed. The radioactivities of the organs were counted using a gamma-counter. The activity per gram tissue was calculated and time versus activity curves were generated. The Tc-99m-ESTACPA uptake by the uterus and ovary such as ER-rich tissues, were observed. The pancreas and stomach also showed a significant uptake.