The sleepy phenotype in mild OSA patients: characteristics and their cardiometabolic risk. Data from the European Sleep Apnea Data Base (ESADA)
Bildiriler > Özet Bildiri
Yazarlar: Izolde Bouloukaki, Marisa Bonsignore, Ludger Grote, Walter Mcnicholas, Jan Hedner, Johan Verbraecken, Silke Ryan, Carolina Lombardi, Özen KAÇMAZ BAŞOĞLU, Athanasia Pataka, Oreste Marrone, Sebastien Bailly, Jean-Louis Pepin, Paschalis Steiropoulos, Sophia Schiza
Clinical respiratory physiology, exercise and functional imaging, , , Uluslararası, Özet Bildiri, ss 2565-2565
DOI: 10.1183/13993003.congress-2020.2565
Özet
Background: A sleepy phenotype is common in patients with moderate to severe obstructive sleep apnoea (OSA). However, its prevalence as well as its association with comorbid conditions is less well characterized in mild OSA patients. Aims and Objectives: To identify the characteristics and the cardiometabolic risk of the sleepy phenotype in mild OSA patients in the European Sleep Apnea Database (ESADA) cohort. Methods: This cross-sectional analysis investigated 10,501 patients from the ESADA cohort with complete data from respiratory polygraphy or polysomnography and the Epworth sleepiness scale (ESS). The predictive value of excessive daytime sleepiness (EDS-ESS>10) on prevalent cardio-metabolic disease was investigated after adjustment for relevant confounding factors including age, obesity and comorbidities. Results: The cohort of mild OSA patients with EDS was younger (51 vs 53yrs, p<0.001) had higher BMI (32 vs 30 kg/m2, p<0.001), higher proportion of females (37 vs 34%), higher prevalence of diabetes (12 vs 10%, p<0.001) and a lower percentage of systemic hypertension (35 vs 38%, p<0.001) compared with the cohort without EDS. Following multivariable analysis, the sleepy phenotype was an independent predictive factor for prevalent diabetes [OR (95% CI) 1.273 (1.047–1.548), p=0.016] and an independent negative predictive factor for systemic hypertension [OR (95% CI) 0.874 (0.767–0.996), p=0.043]. Conclusion: In this large clinical patient cohort, mild OSA patients with a sleepy phenotype were younger, more obese, more likely female and presenting with a higher prevalence of diabetes and lower of hypertension compared to those without EDS.