Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015
Makaleler > Tam Makale · 2016
Yazarlar: IB Tan, Ellen T. Chang, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien, Allan Hildesheim, James D. McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena Devi, L. Li, Y. Zhang, Y. Fan, K. Sun, Z. Du, H. Sun, A. T. Chan, S. W. Tsao, Y. X. Zeng, Q. Tao, Pierre Busson, Claire Lhuillier, Olivier Morales, Dhafer Mrizak, Aurore Gelin, Nikiforos Kapetanakis, Nadira Delhem, Sheila Mansouri, Jennifer Cao, Anup Vaidya, Lori Frappier, Lo Kwok Wai, Sui-Hong Chen, Jin-lin Du, Ming-Fang Ji, Qi-Hong Huang, Qing Liu, Su-Mei Cao, Denise L. Doolan, Anna Coghill, Jason Mulvenna, Carla Proietti, Lea Lekieffre, Jeffrey Bethony, and Allan Hildesheim, Renske Fles, Sagung Rai Indrasari, Camelia Herdini, Santi Martini, Atoillah Isfandiari, Achmad Rhomdoni, Marlinda Adham, Ika Mayangsari, Erik van Werkhoven, Maarten Wildeman, Bambang Hariwiyanto, Bambang Hermani, Widodo Ario Kentjono, Sofia Mubarika Haryana, Marjanka Schmidt, IB Tan, Brian O’Sullivan, Enis Ozyar, Anne W. M. Lee, Mu-Sheng Zeng, Xiaojiang Gao, Minzhong Tang, Pat Martin, Yi Zeng, Mary Carrington, Anna E. Coghill, Wei Bu, Hanh Nguyen, Wan-Lun Hsu, Kelly J. Yu, Pei-Jen Lou, Cheng-Ping Wang, Chien-Jen Chen, Allan Hildesheim, Jeffrey I. Cohen, Ann D. King, Yin-Chu Chien, Wan-Lun Hsu, Kelly J. Yu, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Laio, Yen-Liang Chang, Cheng-Ping Wang, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan Lee
BMC Proceedings, Uluslararası, Scopus, 2016, cilt 10
DOI: 10.1186/s12919-016-0001-5
Özet
The international geographic distribution of NPC is unique among malignancies.Incidence rates can exceed 20 per 100,000 personyears among males and 10 per 100,000 person-years among females in southern China.Intermediate rates are observed in Southeast Asia, North Africa, the Middle East, and the Arctic, as well as among Asian and Pacific Islander migrant populations, while rates generally remain below 1 per 100,000 throughout the rest of the world.The agespecific incidence rate peaks at around 45-59 years in high-incidence areas, whereas a small early incidence peak at ages 15-19 years is followed by a later peak at around 65-79 years in low-incidence areas.The male-to-female incidence ratio is consistently around 2-3 or greater.Much of the striking geographic variation may be attributable to certain risk factors, such as certain HLA alleles and consumption of Chinese-style salted fish, whose geographic distribution mirrors that of NPC.Other NPC risk factors, such as EBV infection, are ubiquitous, yet are almost certainly modified by geographically heterogeneous co-factors.Most established risk factors for NPC are associated with undifferentiated NPC, although tobacco smoking is more strongly associated with squamous cell NPC.The recent worldwide decline in NPC incidence, especially in high-incidence regions, points to an important role of modifiable environmental risk factors that could serve as targets for further disease prevention.