Mismatch repair defects in endometrial cancer
Articles > Article · 2023
Authors: Tuğçe Sırma, Nuri YILDIRIM
Türk Jinekolojik Onkoloji Dergisi, International, 2023
Summary
Endometrial cancer is the most commonly diagnosed gynecologic malignancy among women worldwide and may be classified on the basis of different molecular, pathologic and genetic alterations. Identification of mismatch repair-deficient (MMRd), which occur in up to 30% of all endometrial cancers (EC), has become unavoidable for therapeutic management, clinical desicion making, and prognosis. Although microsatellite instability is associated with a more favorable outcome in colorectal cancer, its relationship with prognosis in EC is not yet clear.