HIPPEASTRINE SYNTHESIS - A COMBINED BIO-DIOXYGENATION ORGANOIRON CHIRALITY RELAY APPROACH
Articles > Article ยท 1993
Authors: Stephen Thomas ASTLEY, M MEYER, GR STEPHENSON
TETRAHEDRON LETTERS, Journal Indexed in SCI Expanded, International, 1993, vol 34, pp 2035-2038
DOI: 10.1016/s0040-4039(00)60339-8
Summary
The regio- and enantioselective preparation of tricarbonyl(eta5-6(S)-endo-methoxy-1(S)-ethoxycyclohexadienyl)iron(1+) hexafluorophosphate(1-) (3, R = OEt), via a biotransformation entry, is described. The optical purity of 3 (R = OEt), which is required as an intermediate for hippeastrine synthesis, was found to be > 98% e.e. by an NMR chiral shift method.