Reversal of doxorubicin-induced vascular dysfunction by resveratrol in rat thoracic aorta: Is there a possible role of nitric oxide synthase inhibition?
Articles > Article · 2009
Authors: Murat OLUKMAN, Cenk CAN, Ayşe EROL, Gülperi ÖKTEM, Onur ORAL, Mehtap Guelcihan Cınar
ANATOLIAN JOURNAL OF CARDIOLOGY, Journal Indexed in SCI Expanded, International, 2009, vol 9, pp 260-266
Summary
Objective: The natural antioxidant, resveratrol has been suggested to protect against doxorubicin-induced cardiotoxicity. Although derangements in nitric oxide (NO) synthesis contribute to vascular endothelial dysfunction caused by doxorubicin, the effects of resveratrol on these parameters have not been evaluated yet. We investigated the impact of resveratrol on doxorubicin-induced vascular dysfunction in rat thoracic aorta with regard to NO synthesis in an experimental, prospective, controlled study.