Labeling of zopiclone with iodine-131
Makaleler > Tam Makale · 1999
Yazarlar: Fatma YURT, P Unak, H Ozkilic, F Uluc, S Bagci, I Tuglular
Nuclear Medicine and Biology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 1999, cilt 26, ss 827-831
DOI: 10.1016/s0969-8051(99)00046-3
Özet
Zopiclone (ZPC) was labeled with I-131 by using the halogen exchange method. Temperature and reaction time effects to labeling yields were studied, Infrared, nuclear magnetic resonance, and gas chromatography-mass spectroscopy spectra were undertaken to identify chemical structure. High performance liquid chromatography (HPLC) was performed to determine purity of cold zopiclone. Biodistribution studies were performed on rabbits and rats. (131)IZPC was administered intravenously to rabbits. Static images were taken by a Sophy DX Gamma Camera. (131)IZPC was also administered intraperitoneally to rats. Activities were counted in a NaI(Tl) scintillation detector for several organs (liver, brain, spleen, lung, blood, fat) after rats were decapitated on different times. Biodistribution profiles were obtained depending on the time. NUCL MED BIOL 26;7:827-831, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.