Comparison of Magnetically Responsive Trimethyl Chitosan and Chitosan Nanoparticles for Gemcitabine Delivery With in Vitro Studies
Articles > Article · 2020
Authors: Ayse Unal, Güliz AK DEMİROZ, Şenay ŞANLIER
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, Journal Indexed in SCI Expanded, International, 2020, vol 4, pp 249-257
DOI: 10.30621/jbachs.2020.1074
Summary
Purpose: Gemcitabine is nucleoside analogue and used for various carcinomas like non-small cell lung cancer. Nanoparticle-based therapeutic agents have been developed for use in cancer therapy. Trimethyl chitosan (TMC) is methylated derivative of chitosan. TMC can be preferable because of the limited solubility of chitosan. Magnetic nanoparticles can be concentrated at cancerous tissue which provide targeted cancer therapy. In this study, we tried to develop and compare magnetically targeted trimethyl chitosan and chitosan nanoparticles for gemcitabine delivery in lung cancer therapy.