Comparison of Magnetically Responsive Trimethyl Chitosan and Chitosan Nanoparticles for Gemcitabine Delivery With in Vitro Studies
Makaleler > Tam Makale · 2020
Yazarlar: Ayse Unal, Güliz AK DEMİROZ, Şenay ŞANLIER
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2020, cilt 4, ss 249-257
DOI: 10.30621/jbachs.2020.1074
Özet
Purpose: Gemcitabine is nucleoside analogue and used for various carcinomas like non-small cell lung cancer. Nanoparticle-based therapeutic agents have been developed for use in cancer therapy. Trimethyl chitosan (TMC) is methylated derivative of chitosan. TMC can be preferable because of the limited solubility of chitosan. Magnetic nanoparticles can be concentrated at cancerous tissue which provide targeted cancer therapy. In this study, we tried to develop and compare magnetically targeted trimethyl chitosan and chitosan nanoparticles for gemcitabine delivery in lung cancer therapy.