The effects of mesenchymal stem cells on lymphoblastic leukemia cell proliferation
Articles > Article · 2014
Authors: Vildan BOZOK, Hüseyin AKTUĞ, Fatih OLTULU, Ahmet KESKİNOĞLU, Buket Erer Del Castello, Dilek TAŞKIRAN
JOURNAL OF BUON, Journal Indexed in SCI Expanded, International, 2014, vol 19, pp 1006-1017
Summary
Purpose: Mesenchymal stein cells (MSCs) represent a new approach to the treatment of several neoplastic or non-neoplastic disorders. Their potential to repair damaged tissues through trans differentiation in conjunction with their immunomodulatory ability made them promising candidates for cell-based immunotherapy and regenerative medicine. In the present study, we aimed to determine the effects of MSCs on proliferation, apoptosis and gene expression profile of the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM.