Radiolabeling of codeine with I-131 and its biodistribution in rats
Makaleler > Tam Makale · 2009
Yazarlar: H. Enginar, P. Unak, Fatma YURT, Fazilet Zümrüt BİBER MÜFTÜLER, E. I. Medine, S. Yolcular, Ayfer YURT KILÇAR, B. Seyitoglu, I. BULDUK
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2009, cilt 280, ss 363-370
DOI: 10.1007/s10967-009-0528-2
Özet
Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with I-131 and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.